To view the seminar recording, please click here Talk Title: mtDNA: the Cinderella of cancer genetics Abstract: Mutation of mitochondrial DNA (mtDNA) can have broad impacts on cell metabolism and organism physiology, and mutation of mtDNA is among the most common somatic alterations to the tumour genome. Mutation of mtDNA is an established cause of […]
To view the seminar recording, please click here Talk Title: Statistical approaches for deciphering gene programs in cancer cells across studies and mutational signatures across ancestries Abstract: Single-cell assays provide valuable insights into the biological processes active in cancer cells within and across tumor samples. However, the majority of single cell RNA-seq (scRNA-seq) studies only […]
To view the seminar recording, please click here Talk Title: Deciphering tissue pathogenesis with spatial sequencing Abstract: Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. In recent years, we developed high-definition spatial transcriptomics and multi-omics technologies, which captures RNA, protein information or microbiota from histological tissue sections […]
