For seminar recording, please click here Talk Title: Some mysteries about viruses and cancer Abstract: It has been estimated that 15%-20% of human cancers are attributable to infections, mostly by carcinogenic viruses. The incidence varies worldwide, with a majority affecting developing countries. Here, we present a comparative analysis of virus-positive and virus-negative tumors in nine...Read More

For seminar recording, please click here Talk Title: Modern Hopfield Networks for Novel Transformer Architectures  Abstract: Modern Hopfield Networks or Dense Associative Memories are recurrent neural networks with fixed point attractor states that are described by an energy function. In contrast to conventional Hopfield Networks, which were popular in the 1980s, their modern versions have...Read More

For seminar recording, please click here Talk Title: Probabilistic Modeling of Dynamics of the Tumor Microenvironment Abstract: Cancer therapies succeed only in a subset of patients partly due to the heterogeneity of cells across and within tumors. Single-cell and spatial genomic technologies present exciting opportunities to characterize unknown cell types in complex tissues such as...Read More

For Meeting Recording, please click here. Passcode: 27097062 Talk Title: Methods for tumor phenotype classification from circulating tumor DNA Abstract: An accurate diagnosis of the tumor histology is essential for clinical care. Aggressive tumor phenotypes can emerge through subtype changes and lineage plasticity as major mechanisms of treatment resistance in cancer. Therefore, distinguishing tumor phenotypes...Read More

For seminar recording, please click here Talk Title: Capturing and exploring the transcriptional and genomic landscape in tissues in health and disease Abstract: Tissue represents an ecosystem of different cells carrying out different tasks. Specific types of cells exist in every organ, and serve specialized functions defined by the specific genes and proteins active in...Read More

For seminar recording, please click here Talk Title: Genomic landscapes of Breast Cancer (Racial/Ancestry) Disparities Abstract: Overview of the emerging findings from genome-wide studies of African-enriched cohorts of breast cancer patients. We will discuss results of multiple ‘omic’ approaches, including genotype associations, whole genome sequence characterizations and transcriptomic studies. Read More

For seminar recording, please click here Talk Title: Systems analysis of ligand effects induced by chromosomal instability on the tumor ecosystem Abstract:  Multicellular programs underly emergent phenotypes in health and disease. Yet, deciphering higher-order functional interactions amongst cell types remains a major challenge. Cell-to-cell communication often takes the form of ligands emanating from “donor” cells...Read More

For seminar recording click here Talk Title: Latent States of Brains and Behavior Abstract: New recording technologies are transforming neuroscience, allowing us to measure the spiking activity of thousands of neurons in freely behaving animals. These technologies offer exciting opportunities to link brain activity to behavioral output, but they also pose serious statistical challenges. Neural...Read More

For seminar recording, please click here Talk Title: Detecting effects of alterations in chromosome structure on cancer cellular fitness Abstract: Structural variants—alterations in chromosome structure—affect far more of the cancer genome than any other type of genetic event. Indeed, large-scale aneuploidies were the first genetic alteration posited to contribute to cancer. Because of their complexity...Read More

Meeting Recording: https://web.microsoftstream.com/video/c84847fc-b1d2-4ec2-a7c3-5243f063cc3f Talk Title: Learning Interpretable Models on Complex Medical Data Abstract: Machine learning as a field has become more and more important due to the ubiquity of data collection in various disciplines. Coupled with this data collection is the hope that new discoveries or knowledge can be learned. My research spans both fundamental...Read More