Talk Title: Coevolution of the cancer genome and MHC in immune surveillance by T cells Talk Summary: Antigen presentation via the Major Histocompatibility Complex Class (MHC) is an essential component of anti-tumor immunity induced by immune checkpoint inhibition. MHC molecules expose peptide fragments on the cell surface, allowing T-Cell elimination of cells displaying antigen […]
Talk Title: Cancer Data Science: Mutation, Selection and Computation Talk Summary: The Gerstung lab develops statistical algorithms to learn more about the causes and consequences of cancer from large data sets. I will provide an overview about recent advances in the areas of cancer evolution, mutational signature analysis, as well as digital pathology and spatial genomics. […]
Talk Title: Enabling the robust characterization of spatial gene expression architecture in tissue sections at increased resolution using Bayesian modeling Talk Summary: New single-cell technologies such as single-cell RNA-seq and high-dimensional flow cytometry enable the unprecedented interrogation of single-cell phenotypes (and functions) under various biological conditions. A common statistical problem is the discovery and characterization […]