To view the seminar recording, please click here Talk Title: Statistical approaches for deciphering gene programs in cancer cells across studies and mutational signatures across ancestries Abstract: Single-cell assays provide valuable insights into the biological processes active in cancer cells within and across tumor samples. However, the majority of single cell RNA-seq (scRNA-seq) studies only […]
Talk Title: mtDNA: the Cinderella of cancer genetics Abstract: Mutation of mitochondrial DNA (mtDNA) can have broad impacts on cell metabolism and organism physiology, and mutation of mtDNA is among the most common somatic alterations to the tumour genome. Mutation of mtDNA is an established cause of multiple hereditary metabolic diseases, with metabolic impacts on […]
For seminar recording, please click here Talk Title: Single-cell Spatial Omics Journey to Signaling and Metabolism of Immunity, Cancer, and Aging Abstract: The spatial organization of cells in tissues and subcellular networks provides a quantitative metric for determining health and disease states. Single-cell analyses of molecular profiles with in-situ detection methods dissect spatial heterogeneity of […]