Talk Title: Dynamic changes of unstable chromosomes: insights from in vitro genome evolution and cancer sequencing Talk Summary: Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their prevalence, how these alterations arise during tumor development remains a mystery. We have gained […]
Talk Title: Coevolution of the cancer genome and MHC in immune surveillance by T cells Talk Summary: Antigen presentation via the Major Histocompatibility Complex Class (MHC) is an essential component of anti-tumor immunity induced by immune checkpoint inhibition. MHC molecules expose peptide fragments on the cell surface, allowing T-Cell elimination of cells displaying antigen […]
Talk Title: Cancer Data Science: Mutation, Selection and Computation Talk Summary: The Gerstung lab develops statistical algorithms to learn more about the causes and consequences of cancer from large data sets. I will provide an overview about recent advances in the areas of cancer evolution, mutational signature analysis, as well as digital pathology and spatial genomics. […]