For invited lecture recording, please click here Talk Title: Quantifying tumor heterogeneity in space and time Abstract: Tumors are heterogeneous mixtures of cancerous and non-cancerous cells that interact in distinct spatial niches and that evolve over time and in response to treatment. Recent spatial transcriptomics technologies measure RNA expression at thousands of locations in a...Read More

For seminar recording, please click here Talk Title: Single-cell Spatial Omics Journey to Signaling and Metabolism of Immunity, Cancer, and Aging Abstract: The spatial organization of cells in tissues and subcellular networks provides a quantitative metric for determining health and disease states. Single-cell analyses of molecular profiles with in-situ detection methods dissect spatial heterogeneity of...Read More

Talk Title: mtDNA: the Cinderella of cancer genetics Abstract: Mutation of mitochondrial DNA (mtDNA) can have broad impacts on cell metabolism and organism physiology, and mutation of mtDNA is among the most common somatic alterations to the tumour genome. Mutation of mtDNA is an established cause of multiple hereditary metabolic diseases, with metabolic impacts on...Read More

To view the seminar recording, please click here Talk Title: Statistical approaches for deciphering gene programs in cancer cells across studies and mutational signatures across ancestries Abstract: Single-cell assays provide valuable insights into the biological processes active in cancer cells within and across tumor samples. However, the majority of single cell RNA-seq (scRNA-seq) studies only...Read More

To view the seminar recording, please click here Talk Title: Deciphering tissue pathogenesis with spatial sequencing Abstract: Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. In recent years, we developed high-definition spatial transcriptomics and multi-omics technologies, which captures RNA, protein information or microbiota from histological tissue sections...Read More

To view the seminar recording, please click here Talk Title: Cellular plasticity and developmental constraints in tumorigenesis and drug resistance Abstract: Cellular plasticity is emerging as an important driving force underlying cancer progression and drug resistance. In this talk, I will discuss the concept of cancer cell states present in the tumor prior to treatment,...Read More

For seminar recording, please click here Talk Title: Comparative spatial omics analysis across length scales Abstract: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues. Such technologies provide the opportunity to evaluate spatial molecular comparisons across healthy versus diseased tissues. In this talk, I will highlight two tools my...Read More

For seminar recording, please click here Talk Title: Artificial Intelligence in Precision Oncology Abstract: Precision oncology requires complex biomarkers which are often based on molecular and genetic tests of tumor tissue. For many of these tests, universal implementation in clinical practice is limited. However, for virtually every cancer patient, pathology tissue slides stained with hematoxylin...Read More

For seminar recording, please click here Talk Title: Using T2T-level comparative genomics to study repeat biology Abstract: Mobile elements and highly repetitive regions are potent sources of lineage-specific genomic innovation and are integral to the structure and function of eukaryotic cells. Recent efforts employing long-read based genome assembly, functional and repeat analyses across multiple marsupial...Read More

For seminar recording, please click here Talk Title: Leveraging mass balance and long DNA molecules to study structural variant mutational processes in cancer Abstract: Genome structure, like other physical phenomena, obeys the simple principle of mass balance. I will show how we can apply this principle algorithmically to assess what structural variants (SVs) are missing from...Read More