For seminar recording, please click here Talk Title: Systems analysis of ligand effects induced by chromosomal instability on the tumor ecosystem Abstract:  Multicellular programs underly emergent phenotypes in health and disease. Yet, deciphering higher-order functional interactions amongst cell types remains a major challenge. Cell-to-cell communication often takes the form of ligands emanating from “donor” cells...Read More

For seminar recording click here Talk Title: Latent States of Brains and Behavior Abstract: New recording technologies are transforming neuroscience, allowing us to measure the spiking activity of thousands of neurons in freely behaving animals. These technologies offer exciting opportunities to link brain activity to behavioral output, but they also pose serious statistical challenges. Neural...Read More

For seminar recording, please click here Talk Title: Detecting effects of alterations in chromosome structure on cancer cellular fitness Abstract: Structural variants—alterations in chromosome structure—affect far more of the cancer genome than any other type of genetic event. Indeed, large-scale aneuploidies were the first genetic alteration posited to contribute to cancer. Because of their complexity...Read More

Meeting Recording: https://web.microsoftstream.com/video/c84847fc-b1d2-4ec2-a7c3-5243f063cc3f Talk Title: Learning Interpretable Models on Complex Medical Data Abstract: Machine learning as a field has become more and more important due to the ubiquity of data collection in various disciplines. Coupled with this data collection is the hope that new discoveries or knowledge can be learned. My research spans both fundamental...Read More

For seminar recording, please click here Talk Title: Dissecting intra-tumor heterogeneity by single cell RNA-seq    Abstract: Each tumor is composed of diverse malignant, immune and stromal cells that interact with one another and collectively determine tumor biology and clinical phenotypes. Over the past nine years, we have been applying single cell RNA-seq (scRNA-seq) to...Read More