Talk Title: Inference of field cancerization using stochastic models to improve cancer control Talk Summary: Early cancer detection strategies focus on screening individuals to find obvious precancerous lesions and removing them when possible. However, screening programs often suffer from both under-diagnosis due to inadequate screening, and over-diagnosis due to ineffective patient stratification in surveillance protocols....Read More

Talk Title: Computational Approaches for Genomics-Guided Pediatric Precision Cancer Medicine Talk Summary: My talk will focus on the methods and computational pipelines we are utilizing in molecular characterization of pediatric cancer patients with rare, relapsed or treatment refractory cancers.  I will illustrate these approaches with specific case examples and a summary of our progress to-date. Read More

Talk Title: Learning to summarize medical evidence Talk Summary: Decisions about patient care should be supported by data. But most clinical evidence — from notes in electronic health records to published reports of clinical trials — is stored as unstructured text and so not readily accessible. The body of such unstructured evidence is already vast...Read More

Talk Title: Enabling the robust characterization of spatial gene expression architecture in tissue sections at increased resolution using Bayesian modeling Talk Summary: New single-cell technologies such as single-cell RNA-seq and high-dimensional flow cytometry enable the unprecedented interrogation of single-cell phenotypes (and functions) under various biological conditions. A common statistical problem is the discovery and characterization...Read More

Talk Title: Cancer Data Science: Mutation, Selection and Computation Talk Summary: The Gerstung lab develops statistical algorithms to learn more about the causes and consequences of cancer from large data sets. I will provide an overview about recent advances in the areas of cancer evolution, mutational signature analysis, as well as digital pathology and spatial genomics....Read More

Talk Title: Coevolution of the cancer genome and MHC in immune surveillance by T cells   Talk Summary: Antigen presentation via the Major Histocompatibility Complex Class (MHC) is an essential component of anti-tumor immunity induced by immune checkpoint inhibition. MHC molecules expose peptide fragments on the cell surface, allowing T-Cell elimination of cells displaying antigen...Read More

Talk Title: Dynamic changes of unstable chromosomes: insights from in vitro genome evolution and cancer sequencing   Talk Summary: Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their prevalence, how these alterations arise during tumor development remains a mystery. We have gained...Read More

Talk Title: Digital Transformation @ MSK Talk Summary: A discussion of digital transformation and what it means for MSK; focusing on digital vision and what we currently know about execution plans. The discussion will address both internal and external aspects of our journey, as well as the opportunities and pitfalls involved. In particular we will...Read More