Jian Carrot-Zhang, PhD

Jian
Assistant Member
Contact
Genesis Pineda 646.608.7645

About

Dr. Jian Carrot-Zhang, PhD, is a new Assistant Member in the Computational Oncology Service. Her research focuses on understanding germline-somatic interactions in multi-ethnic populations. She develops computational and statistical approaches to characterize ancestral effects on the cancer genomes. Dr. Carrot-Zhang holds a joint appointment in the Clinical Genetics Service of the Department of Medicine to bridge the gap between germline genetics and somatic genomics. She has also led multiple research projects in collaboration with The Cancer Genome Atlas (TCGA) research network. Dr. Carrot-Zhang obtained her PhD in Human Genetics from McGill University and has trained at Dana-Farber Cancer Institute as a postdoctoral research fellow with Dr. Matthew Meyerson. Prior to MSKCC, she was an Instructor in Medicine in Harvard Medical School. Dr. Carrot-Zhang authored many publications in high-ranking journals and holds several awards including a K99 Award from NCI and a Banting Fellowship from CIHR.
The Carrot-Zhang Lab

Education

PhD

McGill University

Postdoctoral Research

Dana-Farber Cancer Institute, Harvard Medical School, and Broad Institute, MA

 

Appointments

Computational Oncology, Department of Epidemiology & Biostatistics

Gerstner Sloan Kettering Faculty Member

Selected Publications

Nassar AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J, Gusev A. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors. Cancer Cell. 2022 Oct 10;40(10):1161-1172.e5. doi: 10.1016/j.ccell.2022.08.022. Epub 2022 Sep 29. PMID: 36179682; PMCID: PMC9559771.

Carrot-Zhang J, Han S, Zhou W, Damrauer JS, Kemal A; Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R. Analytical protocol to identify local ancestry-associated molecular features in cancer. STAR Protoc. 2021 Sep 20;2(4):100766. doi: 10.1016/j.xpro.2021.100766. PMID: 34585150; PMCID: PMC8456058.

Carrot-Zhang J, Soca-Chafre G, Patterson N, Thorner AR, Nag A, Watson J, Genovese G, Rodriguez J, Gelbard MK, Corrales-Rodriguez L, Mitsuishi Y, Ha G, Campbell JD, Oxnard GR, Arrieta O, Cardona AF, Gusev A, Meyerson M. Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations. Cancer Discov. 2021 Mar;11(3):591-598. doi: 10.1158/2159-8290.CD-20-1165. Epub 2020 Dec 2. PMID: 33268447; PMCID: PMC7933062.

Carrot-Zhang J, et al., Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R. Comprehensive Analysis of Genetic Ancestry and its molecular correlates in cancer. Cancer Cell 2020; 37 (5) 639-654.

Carrot-Zhang J, et al. Meyerson M, Govindan R, Imielinski M.  Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway Cell Rep. 2021 Feb 2;34(5):108707. doi: 10.1016/j.celrep.2021.108707. PMID: 33535033