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Talk Title:

Detecting effects of alterations in chromosome structure on cancer cellular fitness

Abstract:

Structural variants—alterations in chromosome structure—affect far more of the cancer genome than any other type of genetic event. Indeed, large-scale aneuploidies were the first genetic alteration posited to contribute to cancer. Because of their complexity and long-range genomic effects, however, their impacts on cancer evolution have been poorly defined. Even the genes that account for those impacts are not known for many of the most common structural variants. We describe new methods to interrogate structural variants including large-scale aneuploidies and their implications for cancer development and progression.