Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic...Read More

The digitization of health records and growing availability of tumour DNA sequencing provide an opportunity to study the determinants of cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text and siloed datasets. Here we combine natural language processing annotations1,2 with structured medication, patient-reported demographic, tumour registry and tumour genomic data from 24,950...Read More

Dr. Adam Weiner published the paper Inferring replication timing and proliferation dynamics from single-cell DNA sequencing data. The study explores how dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle dynamics remain understudied in aneuploid tumors. We...Read More

Dr. Nicholas Ceglia et al. published the paper Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector. A scalable framework for dimensionality reduction, GeneVector identifies transcriptional programs and classifies cell types. You can read the paper in Nature Communications here.Read More