A new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK) offers critical insights into how high-grade serous ovarian carcinoma — the most common and aggressive form of ovarian cancer — evolves. Published July 16 in Nature, the study used single-cell sequencing to explore a process called whole-genome doubling (WGD), in which cancer...Read More

Whole-genome doubling (WGD) is a common feature of human cancers and is linked to tumour progression, drug resistance, and metastasis1,2,3,4,5,6. Here we examine the impact of WGD on somatic evolution and immune evasion at single-cell resolution in patient tumours. Using single-cell whole-genome sequencing, we analysed 70 high-grade serous ovarian cancer samples from 41 patients (30,260...Read More