Dr. Elli Papaemmanuil et al. published the paper Clonal evolution during metastatic spread in high-risk neuroblastoma. Patients with high-risk neuroblastoma generally present with widely metastatic disease and often relapse despite intensive therapy. As most studies to date focused on diagnosis-relapse pairs, our understanding of the genetic and clonal dynamics of metastatic spread and disease progression...Read More

Dr. Benjamin Greenbaum et al. published the paper Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients, yet harbours mutation-derived T cell neoantigens that are suitable for vaccines. Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex...Read More