Dr. Benjamin Greenbaum co authored the paper “Fundamental immune–oncogenicity trade-offs define driver mutation fitness” along with David Hoyos et al. in the journal Nature. In it, they propose a unified theoretical ‘free fitness’ framework that parsimoniously integrates multimodal genomic, epigenetic, transcriptomic and proteomic data into a biophysical model of the rate-limiting processes underlying the fitness advantage conferred on cancer cells by driver gene mutations. Focusing on TP53, the most mutated gene in cancer1, they present an inference of mutant p53 concentration and demonstrate that TP53 hotspot mutations optimally solve an evolutionary trade-off between oncogenic potential and neoantigen immunogenicity.
You can read the paper in Nature here.