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X-WR-CALDESC:Events for Computational Oncology
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DTSTART;TZID=America/New_York:20200430T140000
DTEND;TZID=America/New_York:20200430T150000
DTSTAMP:20260426T083059
CREATED:20200427T140031Z
LAST-MODIFIED:20200528T200719Z
UID:5215-1588255200-1588258800@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. CZ Zhang
DESCRIPTION:Talk Title: \nDynamic changes of unstable chromosomes: insights from in vitro genome evolution and cancer sequencing \n \nTalk Summary: \nCopy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their prevalence\, how these alterations arise during tumor development remains a mystery. We have gained significant insight into this question by two lines of research. In the first approach\, we analyzed genomic alterations induced by unstable chromosomes and their evolution over multiple generations by single-cell sequencing. We found that even a single broken chromosome in an ancestor cell can cause highly dynamic evolution and generate extensive genetic diversity in the progeny population\, giving rise to all forms of alterations in cancer genomes\, including focal amplification and deletion\, arm-level copy-number changes\, and complex rearrangements. This finding led us to hypothesize that the genetic diversity due to unstable chromosomes may fuel the transition from pre-malignancy to cancer. In the second approach\, we performed whole-genome sequencing on esophageal adenocarcinomas and matching precursor lesions from the same patients to track the evolution of chromosomal alterations during disease progression. The analysis of tumor genomes revealed a trajectory of genome evolution from benign to malignancy that bears a striking similarity to the evolution of unstable chromosomes in the in vitro experiments. Together\, our results suggest that a few simple mechanisms of chromosomal evolution may be sufficient to create the enormous complexity of cancer genomes and the evolution of unstable genomes may be not completely chaotic after all.
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-cz-zhang/
LOCATION:Virtual
CATEGORIES:Seminar Series
ATTACH;FMTTYPE=application/pdf:https://componcmsk.org/wp-content/uploads/2020/04/CZ-Zhang-Flyer.pdf
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200218T100000
DTEND;TZID=America/New_York:20200218T110000
DTSTAMP:20260426T083059
CREATED:20200212T211557Z
LAST-MODIFIED:20200212T211557Z
UID:5196-1582020000-1582023600@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Claus T. Jensen
DESCRIPTION:Talk Title: \nDigital Transformation @ MSK \nTalk Summary: \nA discussion of digital transformation and what it means for MSK; focusing on digital vision and what we currently know about execution plans. The discussion will address both internal and external aspects of our journey\, as well as the opportunities and pitfalls involved. In particular we will cover how the ability to crunch more data\, with larger variety of source\, impact data driven research in general and computational oncology in particular. In all likelihood we are moving towards a cancer model where digital diagnostics and treatments become an integral part of a hybrid care model.
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-claus-t-jensen/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
ATTACH;FMTTYPE=application/pdf:https://componcmsk.org/wp-content/uploads/2020/02/Claus-Jensen-Lobby-Poster.pdf
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200128T100000
DTEND;TZID=America/New_York:20200128T110000
DTSTAMP:20260426T083059
CREATED:20200127T140003Z
LAST-MODIFIED:20200128T003218Z
UID:5179-1580205600-1580209200@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Nicky McGranahan
DESCRIPTION:
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-nicky-mcgranahan/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
ATTACH;FMTTYPE=image/png:https://componcmsk.org/wp-content/uploads/2020/01/Nicky-SS-Poster.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191210T100000
DTEND;TZID=America/New_York:20191210T110000
DTSTAMP:20260426T083059
CREATED:20190628T185442Z
LAST-MODIFIED:20190919T122049Z
UID:1605-1575972000-1575975600@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Peter van Loo
DESCRIPTION:
URL:https://componcmsk.org/event/computational-oncology-seminar-series-peter-van-loo/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191105T153000
DTEND;TZID=America/New_York:20191105T163000
DTSTAMP:20260426T083059
CREATED:20190628T185314Z
LAST-MODIFIED:20190707T214442Z
UID:1602-1572967800-1572971400@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Eytan Ruppin
DESCRIPTION:
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-eytan-ruppin/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191015T100000
DTEND;TZID=America/New_York:20191015T110000
DTSTAMP:20260426T083059
CREATED:20190628T185147Z
LAST-MODIFIED:20190628T185147Z
UID:1600-1571133600-1571137200@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Christina Curtis
DESCRIPTION:
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-christina-curtis/
LOCATION:Day 1: MSK Rockefeller Research Laboratories
Day 2: MSK Joy Building
\, Memorial Sloan Kettering Cancer Center\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190904T153000
DTEND;TZID=America/New_York:20190904T163000
DTSTAMP:20260426T083059
CREATED:20190628T184335Z
LAST-MODIFIED:20190628T184335Z
UID:1595-1567611000-1567614600@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. John Marioni
DESCRIPTION:
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-john-marioni/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190611T100000
DTEND;TZID=America/New_York:20190611T110000
DTSTAMP:20260426T083059
CREATED:20190628T181524Z
LAST-MODIFIED:20190725T153809Z
UID:1588-1560247200-1560250800@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Rahul Satija
DESCRIPTION:Integration of single-cell data across technologies\, modalities\, and species\n \nDr. Rahul Satija\nCore Faculty Member\, New York Genome Center \nAssistant Professor\, Biology\, New York Genome Center
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-rahul-satija/
LOCATION:Day 1: MSK Rockefeller Research Laboratories
Day 2: MSK Joy Building
\, Memorial Sloan Kettering Cancer Center\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190521T153000
DTEND;TZID=America/New_York:20190521T163000
DTSTAMP:20260426T083059
CREATED:20190723T185814Z
LAST-MODIFIED:20190725T153843Z
UID:4035-1558452600-1558456200@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Núria López-Bigas
DESCRIPTION:Tumor genomes shed light into somatic mutational processes and cancer vulnerabilities\n \nDr. Núria López-Bigas\nICREA Research Professor\nInstitute for Research in Biomedicine\n(IRB Barcelona)
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-nuria-lopez-bigas/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190402T153000
DTEND;TZID=America/New_York:20190402T163000
DTSTAMP:20260426T083059
CREATED:20190723T185621Z
LAST-MODIFIED:20190725T154110Z
UID:4032-1554219000-1554222600@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. David Wedge
DESCRIPTION:The Genomics of Cancer Evolution and Metastasis\n \nDr. David Wedge\nGroup Leader in Cancer Genomics\nBig Data Institute\nUniversity of Oxford
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-david-wedge/
LOCATION:Day 1: MSK Rockefeller Research Laboratories
Day 2: MSK Joy Building
\, Memorial Sloan Kettering Cancer Center\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190325T103000
DTEND;TZID=America/New_York:20190325T113000
DTSTAMP:20260426T083059
CREATED:20190723T185457Z
LAST-MODIFIED:20190725T154304Z
UID:4029-1553509800-1553513400@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Dan Landau
DESCRIPTION:Charting normal and malignant blood cell evolutionary topographies with multi-modality single-cell genomics\n \nDr. Dan Landau\nAssistant Professor of Medicine\nDivision of Hematology and Medical Oncology\nAssistant Professor of Physiology and Biophysics\nWeill Cornell Medical College\nCore Member\, New York Genome Center
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-dan-landau/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190205T153000
DTEND;TZID=America/New_York:20190205T163000
DTSTAMP:20260426T083059
CREATED:20190723T185323Z
LAST-MODIFIED:20190725T154342Z
UID:4026-1549380600-1549384200@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Daniel De Carvalho
DESCRIPTION:Epigenetics and Cancer Biology:\nFrom Viral Mimicry to Liquid Biopsies\n \nDr. Daniel De Carvalho \nSenior Scientist\, Associate Professor\nPrincess Margaret Cancer Centre
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-daniel-de-carvalho/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190108T153000
DTEND;TZID=America/New_York:20190108T163000
DTSTAMP:20260426T083059
CREATED:20190723T185055Z
LAST-MODIFIED:20190725T153341Z
UID:4010-1546961400-1546965000@componcmsk.org
SUMMARY:Computational Oncology Seminar Series\, Dr. Ben Raphael
DESCRIPTION:Clonal Heterogeneity and Evolution in Primary Tumors and Metastases\n \nDr. Ben Raphael \nProfessor\, Department of Computer Science \nPrinceton University
URL:https://componcmsk.org/event/computational-oncology-seminar-series-dr-ben-raphael/
LOCATION:Zuckerman Research Center Auditorium\, 417 E 68th Street\, New York\, NY\, 10065\, United States
CATEGORIES:Seminar Series
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