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X-WR-CALDESC:Events for Computational Oncology
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DTSTART;TZID=America/New_York:20241015T100000
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DTSTAMP:20260423T183742
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UID:7747-1728986400-1728990000@componcmsk.org
SUMMARY:The Halvorsen Center for Computational Oncology Invited Lecture Series\, Dr. Mario L. Suvà
DESCRIPTION:Talk Title:\nDissecting gliomas by single-cell and spatial genomics \nAbstract: In my lecture\, I will discuss recent efforts we have undertaken in the lab to\ncharacterize the architecture of glioblastoma and its temporal evolution after standard of\ncare therapy by single-cell and spatial genomics. I will also discuss novel approaches that we\nhave developed to model the complexity of the glioblastoma ecosystem in the lab. \n\n 
URL:https://componcmsk.org/event/the-halvorsen-center-for-computational-oncology-invited-lecture-series-dr-mario-l-suva/
LOCATION:MSKCC- Main Campus 1275 York Avenue (68th Street) Room M107 New York\, New York 10065\, 1275 York Avenue\, New York\, NY\, 10065\, United States
CATEGORIES:Invited Lecture Series,Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://componcmsk.org/wp-content/uploads/2024/10/Mario-L.-Suva-Info-10.2024-scaled.jpg
ORGANIZER;CN="Genesis Pineda":MAILTO:Componcmsk@gmail.com
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DTSTART;TZID=America/New_York:20240917T100000
DTEND;TZID=America/New_York:20240917T110000
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CREATED:20240906T143927Z
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UID:7679-1726567200-1726570800@componcmsk.org
SUMMARY:The Halvorsen Center for Computational Oncology Invited Lecture Series\, Dr. Jellert Gaublomme
DESCRIPTION:Talk Title:\nIn Situ Mapping of Cancer Mechanisms and Microenvironments via Pooled Perturbations \nAbstract: \n We developed CRISPRmap\, a novel in situ barcode readout approach with concurrent multiplexed immunofluorescence and in situ RNA detection. CRISPRmap reduces both dependency on third party proprietary sequencing reagents and assay cost. We conducted a multi-omic base-editing screen in a breast cancer context on core DNA damage repair genes involved in the homologous recombination and Fanconi anemia pathways. Our approach enabled us to pinpoint likely-pathogenic patient-derived mutations that were previously classified as variants of unknown clinical significance. Furthermore\, CRISPRmap effectively distinguished barcodes of a pooled library in tumor tissue\, and we coupled it with cell-type and molecular phenotyping by cyclic immunofluorescence. Multi-omic spatial analysis of how CRISPR-perturbed cells respond to various environmental cues in the tissue context offers the potential to significantly expand our understanding of tissue biology in both health and disease.\n 
URL:https://componcmsk.org/event/the-halvorsen-center-for-computational-oncology-invited-lecture-series-dr-jellert-gaublomme/
LOCATION:MSK Rockefeller Research Laboratories Auditorium 120\, 430 E 67th St\, New York\, NY\, 10065\, United States
CATEGORIES:Invited Lecture Series,Seminar Series
ATTACH;FMTTYPE=image/jpeg:https://componcmsk.org/wp-content/uploads/2024/09/Jellert-Gaublomme-Info-09.2024-scaled.jpg
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